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Anti Inflammation - 60 capsules

Anti Inflammation - 60 capsules

from Gods Rage
€19,90 - €19,90
€19,90
€19,90
€19,90 - €19,90
€19,90
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If you push yourself to the limit in the gym and train hard, you expose your body to great stress. Increased inflammation levels can hardly be avoided, which can have a number of disadvantages. Anti Inflammation by Gods Rage ensures with its active ingredient matrix that your inflammation levels do not roll over and that nothing stands in the way of your PRs in the gym.

  • Ingredients with pronounced anti-inflammatory effects
  • Effect proven by studies
  • Based on active plant ingredients
  • High dose ingredients
  • Potent active ingredient matrix
  • Easy to dose capsule form
  • Highest quality - Made in Germany
Nutritional values and ingredients
Compositionper 2 capsule% (NRV*)
Bromelain650 mg**
Turmeric rootstock extract264 mg**
thereof curcuminoids251 mg**
Chinese golden root extract200 mg**
Of which berber100 mg**
Black pepper extract5.0 mg**
thereof piperine4.75 mg**


Ingredients: Bromelain, turmeric rhizome extract 50:1 (Curcuma longa, contains 95% curcuminoids), coating agent: hydroxypropylmethylcellulose (vegetable capsule shell), Chinese golden root extract 25:1 (Coptis chinensis, contains 50% berberine), black pepper extract (contains 95% piperine).

*Percent of the recommended daily intake according to Regulation (EU) No. 1196/2011.

**No nutrient reference values (NRV) available.

Consumption recommendation
Take two (2) capsules once a day unchewed
Notes

Do not exceed the specified recommended daily intake. Food supplements should not be used as a substitute for a balanced and varied diet. The product should be stored out of reach of small children.

Sources
  1. Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011;17:6-63.
  2. Paulsen G, Mikkelsen UR, Raastad T, et al. Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise? Exerc Immunol Rev. 2012;18:42-97.
  3. Febbraio MA, Pedersen BK. Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev. 2005;33(3):114-119.
  4. Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol. 2005;288(2):R345-R353.
  5. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes. 2009;58(1):30-38.
  6. Herder C, Schneitler S, Rathmann W, et al. Low-grade inflammation, obesity, and insulin resistance in adolescents. J Clin Endocrinol Metab. 2007;92(12):4569-4574.
  7. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327-334.
  8. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107(3):391-397.
  9. Ford ES, Giles WH, Mokdad AH, Myers GL. Distribution and correlates of C-reactive protein concentrations among adult US women. Clin Chem. 2004;50(3):574-581.
  10. Engelhart MJ, Geerlings MI, Meijer J, et al. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam Study. Arch Neurol. 2004;61(5):668-672.
  11. Lai SW, Chen JH, Lin HY, Liu CS, Li TC, Tsai CF. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr). 2014;36(1):363-370.
  12. Brien S, Lewith GT, et al. Bromelain as an adjunctive treatment for osteoarthritis of the knee: a randomized controlled pilot study. QJM. 2006;99(12):841-850. doi: 10.1093/qjmed/hcl119
  13. Hale LP, Greer PK, Trinh CT, et al. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin Immunol. 2005;116(2):135-142. doi: 10.1016/j.clim.2005.03.003
  14. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-1245. doi: 10.1007/PL00000936
  15. Miller PC, Bailey SP, Barnes ME, et al. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci. 2004;22(4):365-372. doi: 10.1080/02640410310001655881
  16. Secor ER Jr, Singh A, et al. Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro. Int Immunopharmacol. 2009;9(3):340-346. doi: 10.1016/j.intimp.2008.11.007
  17. Kheirouri S, Alizadeh M. Berberine natural alkaloid improves diabetic retinopathy through modulation of oxidative stress, inflammation and gene expression. Biomed Pharmacother. 2019;109:547-557. doi: 10.1016/j.biopha.2018.10.012
  18. Zhou Y, Ren Y, Zhang X, et al. Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice via suppression of the TLR4/NF-κB signaling pathway. Drug Des Devel Ther. 2018;12:775-783. doi: 10.2147/DDDT.S158337
  19. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-153. PMID: 19594223.
  20. Daily JW, Yang M, et al. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717-729. doi: 10.1089/jmf.2016.3705
  21. Kuptniratsaikul V, Dajpratham P, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. doi: 10.2147/CIA.S58535
  22. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. doi: 10.1089/107555303321223035. PMID: 12676044.
  23. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jun 25. PMID: 18662800.
  24. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 1999 May 1;163(9):3474-83. PMID: 10553082.

 

Content: 60 capsules Item No.: 7378

Inflammation is an important aspect of athletic success, supporting healing and recovery after a hard workout (1). Brief, acute exercise-induced inflammatory responses are critical for muscle growth and increased strength (2). They initiate important growth processes and promote glucose uptake by the muscles (3). Otherwise, they also play a critical role in converting dormant satellite cells into fully developed muscle cells (4) and can lower myostatin levels that may otherwise limit muscle growth (5). Thus, without inflammation, neither ideal muscle growth nor optimal strength gains would be possible. But unfortunately, inflammation can also quickly get out of hand, causing inflammation levels to rise too high. The consequences of this can include not only severely limited recovery or joint and muscle pain. Chronic inflammation is one of the triggers for many diseases and illnesses. Studies have found links between highly elevated levels of inflammation and diseases such as diabetes, heart disease, obesity, and Alzheimer's disease (6,7,8,9,10,11).

Ingredients of Anti Inflammation

Anti Inflammation by Gods Rage with its potent active ingredient matrix can help relieve inflammation and thereby accelerate regeneration processes. For this purpose, Anti Inflammation uses highly effective herbal active ingredients. These have been used for years in the field of traditional medicine of various cultures and their effect has been proven in numerous studies. One ingredient used in Anti Inflammation is bromelain. Bromelain is an enzyme that occurs naturally in the pineapple fruit. It is primarily known for its protein digestion and absorption support properties. But it also has a strong anti-inflammatory effect. According to researchers, this is due in part to its ability to reduce the body's levels of the pro-inflammatory compounds cyclooxygenase-2 (COX2), TNF-alpha, TNF-beta, IFN-y and prostaglandin E2 (PGE-2) (12). Similarly, bromelain blocked the production of pro-inflammatory cytokines in subjects of a scientific study via inhibition of ERK-2 transmission (12). Bromelain appears to be particularly effective for joint conditions such as arthritis. In studies, it not only relieved joint pain and swelling, but also reduced joint stiffness in test subjects (13,14). In addition to this, in one study, bromelain was able to reduce muscle soreness after a workout and significantly accelerate the healing of exercise-related muscle damage (15,16). Another ingredient used is berberine. Berberine is an alkaloid that can be obtained from barberry, among other plants. It has been used for several years in various ancient medical systems such as traditional Chinese medicine and Indian Ayurvedic medicine. Although berberine is primarily known for its blood sugar-lowering effects, it also has pronounced anti-inflammatory effects according to scientific studies (17,18). These ingredients are complemented by curcumin. Curcumin is particularly known for its potent anti-inflammatory properties, which studies have shown to rival even some anti-inflammatory drugs (19,20,21). According to researchers, these effects are based, among other things, on inhibition of endogenous pro-inflammatory compounds such as COX-2, TNF-alpha, and NF-KB, which play a key role in chronic inflammation (19,22). In this context, it is also interesting that curcumin was able to combat inflammation at the molecular level in a study (23,24).

Anti Inflammation by Gods Rage combines potent ingredients to provide optimal support for your body when it comes to fighting inflammation levels. This means that nothing stands in your way on your way to greater performance. So what are you waiting for, Valhalla is calling you.

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