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Citrus Bergamot - 90 capsules

Citrus Bergamot - 90 capsules

from GN Laboratories
€29,90 - €29,90
€29,90
€29,90
€29,90 - €29,90
€29,90
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Citrus Bergamot is an active ingredient that has enjoyed growing popularity among strength athletes over the past several years. It is said to improve cholesterol and blood lipid levels (1), inhibit inflammation (2), and protect cardiovascular health through multiple pathways (3). As always, GN brings the active ingredient in its usual top quality and standardized 35% polyphenols, so nothing stands in the way of optimal effect. Citrus Bergamot by GN Laboratories - because in the end only results count.

  • Possesses a whole range of positive effects
  • Influences cholesterol and blood lipid levels (1)
  • Anti-inflammatory properties (2)
  • Easy to dose capsule form
  • Highest quality - Made in Germany
Nutritional values and ingredients
CompositionPer capsules% of the reference amount (NRV*)
Citrus Bergamot500 mg**
of which 35% polyphenols175 mg**


Ingredients: Citrus bergamot extract (35% polyphenols),Releasing agent: rice bran extract, capsule shell: hydroxypropylmethylcellulose.

*Percent of the recommended daily intake according to Regulation (EU) No. 1196/2011.

**No nutrient reference values (NRV) available.

Consumption recommendation

Take 1-3 capsules daily throughout the day with plenty of liquid.

Notes

Do not exceed the specified recommended daily intake. Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Keep out of reach of children

Sources
  1. Nauman MC, Johnson JJ. Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers. Integr Food Nutr Metab. 2019 Mar;6(2):10.15761/IFNM.1000249. doi: 10.15761/IFNM.1000249. epub 2019 Feb 28. PMID: 31057945; PMCID: PMC6497409.
  2. Ferlazzo N, Cirmi S, Calapai G, Ventura-Spagnolo E, Gangemi S, Navarra M. Anti-inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules. 2016 Sep 23;21(10):1273. doi: 10.3390/molecules21101273. PMID: 27669206; PMCID: PMC6274179.
  3. Toth PP, Patti AM, Nikolic D, Giglio RV, Castellino G, Biancucci T, Geraci F, David S, Montalto G, Rizvi A, Rizzo M. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Front Pharmacol. 2016 Jan 6;6:299. doi: 10.3389/fphar.2015.00299. PMID: 26779019; PMCID: PMC4702027.
  4. Da Pozzo E, De Leo M, Faraone I, Milella L, Cavallini C, Piragine E, Testai L, Calderone V, Pistelli L, Braca A, Martini C. Antioxidant and Antisenescence Effects of Bergamot Juice. Oxid Med Cell Longev. 2018 Jul 12;2018:9395804. doi: 10.1155/2018/9395804. PMID: 30116497; PMCID: PMC6079356.
  5. Cappello AR, Dolce V, Iacopetta D, Martello M, Fiorillo M, Curcio R, Muto L, Dhanyalayam D. Bergamot (Citrus bergamia Risso) flavonoids and their potential benefits in human hyperlipidemia and atherosclerosis: an overview. Mini Rev Med Chem. 2016;16(8):619-29. doi: 10.2174/1389557515666150709110222. PMID: 26156545.
  6. Schoeneck M, Iggman D. The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2021 Elzbieta Janda, Antonella Lascala, Concetta Martino, Salvatore Ragusa, Saverio Nucera, Ross Walker, Santo Gratteri, Vincenzo Mollace,
  7. Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids, PharmaNutrition, Volume 4, Supplement, 2016, Pages S8-S18, ISSN 2213-4344,May 6;31(5):1325-1338. doi: 10.1016/j.numecd.2020.12.032. epub 2021 Jan 16. PMID: 33762150.
  8. Huang Y, Tocmo R, Nauman MC, Haughan MA, Johnson JJ. Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells. Nutrients. 2021 Sep 10;13(9):3156. doi: 10.3390/nu13093156. PMID: 34579033; PMCID: PMC8469228.
  9. Lamiquiz-Moneo I, Giné-González J, Alisente S, Bea AM, Pérez-Calahorra S, Marco-Benedí V, Baila-Rueda L, Jarauta E, Cenarro A, Civeira F, Mateo-Gallego R. Effect of bergamot on lipid profile in humans: a systematic review. Crit Rev Food Sci Nutr. 2020;60(18):3133-3143. doi: 10.1080/10408398.2019.1677554. epub 2019 Oct 31. PMID: 31670973.
  10. Perna S, Spadaccini D, Botteri L, Girometta C, Riva A, Allegrini P, Petrangolini G, Infantino V, Rondanelli M. Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations. Food Sci Nutr. 2019 Jan 25;7(2):369-384. doi: 10.1002/fsn3.903. PMID: 30847114; PMCID: PMC6392855.
  11. Ritchie AI, Wedzicha JA. Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations. Clin Chest Med. 2020 Sep;41(3):421-438. doi: 10.1016/j.ccm.2020.06.007. PMID: 32800196; PMCID: PMC7423341.
  12. de Cássia da Silveira E Sá R, Lima TC, da Nóbrega FR, de Brito AEM, de Sousa DP. Analgesic-Like Activity of Essential Oil Constituents: an update. Int J Mol Sci. 2017 Dec 9;18(12):2392. doi: 10.3390/ijms18122392. PMID: 29232831; PMCID: PMC5751100.
  13. Lombardo GE, Cirmi S, Musumeci L, Pergolizzi S, Maugeri A, Russo C, Mannucci C, Calapai G, Navarra M. Mechanisms Underlying the Anti-Inflammatory Activity of Bergamot Essential Oil and Its Antinociceptive Effects. Plants (Basel). 2020 Jun 1;9(6):704. doi: 10.3390/plants9060704. PMID: 32492797; PMCID: PMC7356015.
  14. Bartella L, Mazzotti F, Talarico IR, De Luca G, Santoro I, Prejanò M, Riccioni C, Marino T, Di Donna L. Structural Characterization of Peripolin and Study of Antioxidant Activity of HMG Flavonoids from Bergamot Fruit. Antioxidants (Basel). 2022 Sep 20;11(10):1847. doi: 10.3390/antiox11101847. PMID: 36290571; PMCID: PMC9598738.
  15. Mare R, Mazza E, Ferro Y, Gliozzi M, Nucera S, Paone S, Aversa I, Pujia R, Marafioti G, Musolino V, Mollace V, Montalcini T, Pujia A. A new breakfast brioche containing bergamot fiber prevents insulin and glucose increase in healthy volunteers: a pilot study. Minerva Endocrinol (Torino). 2021 Jun;46(2):214-225. doi: 10.23736/S2724-6507.20.03243-5. epub 2020 Sep 24. PMID: 32969628.

Content: 90 capsules Item No.: 7642

What is Citrus Bergamot?

Bergamot is a citrus plant that originated as a cross between the bitter orange and other citrus plants and was first described in the 17th century. Since that time, bergamot has been cultivated in Italy, mainly on the coast of Calabria. The extracts obtained from the plant give Earl Grey tea its characteristic aroma, and the essential oils of bergamot are used in perfumery and aromatherapy. What was unclear for a long time is that bergamot is very rich in polyphenols. These, just like the essential oils of bergamot, have a variety of health benefits and, in addition, according to studies, also have pronounced antioxidant properties (4).

How can Citrus Bergamot improve cardiovascular health?

Citrus Bergamot is an active ingredient that was able to improve cholesterol and blood lipid levels in subjects in a study. Elevated levels in these areas represent two of the primary risk factors for cardiovascular disease (5). These risk factors are becoming increasingly important in today's world and affect not only people who do not exercise enough, but also athletes who have unhealthy dietary habits (6). High levels of harmful LDL cholesterol promote deposits in blood vessels that can lead to narrowing or occlusion, and thus are the primary trigger for a heart attack. Healthy HDL cholesterol counteracts such deposits by promoting the removal of LDL cholesterol. Scientific studies have shown that Citrus Bergamot was able to significantly reduce harmful LDL cholesterol levels. At the same time, it was able to significantly increase levels of healthy HDL cholesterol (1,3, 8). In addition to this, a significant reduction in blood triglyceride levels was also observed. In contrast to statins, which are used in the medical field as cholesterol-lowering agents, Citrus Bergamot does not inhibit the body's own production of coenzyme Q10 (9). Another benefit that has been associated in studies with the intake of Citrus Bergamot is its property as an antioxidant that can counteract oxidation of LDL cholesterol (4). This is of particular interest because oxidized LDL cholesterol can contribute to plaque formation in the blood vessels (i.e., calcification of the veins) to a much greater extent than intact LDL cholesterol (1,3).

Other effects of Citrus Bergamot proven in studies

Citrus Bergamot has been associated with helping to keep blood vessels healthy (10). Chronic systemic inflammation is widespread and has been associated with an increased risk of many diseases, including cardiovascular disease (11). Particularly critical in this regard, is the inner lining of the veins known as the endothelium, which is directly involved in vein dilation , blood pressure regulation, blood clotting, and many other important processes. In volunteers, Citrus Bergamot was shown to reduce inflammation and plaque formation and improve elasticity and responsiveness of the veins. This is due in part to its pronounced anti-inflammatory properties, which result from a reduction in levels of pro-inflammatory cytokines (3, 12, 13). In addition to this, Citrus Bergamot has been shown to protect the cells of the endothelium from free radical damage through its antioxidant properties, which has also been shown to promote endothelial and consequently vascular health (4, 14). Another effect of bergamot is related to insulin sensitivity. Scientific studies have shown that citrus bergamot can improve insulin sensitivity via activation of AMPK, resulting in a significant reduction in blood glucose levels (10,15).

Citrus Bergamot is a supplement that could really come up with numerous positive effects in test subjects of various studies. It comes as little surprise that the active ingredient is also becoming increasingly popular in Germany. As always, the effect of the supplement stands and falls with the quality of the ingredients. GN relies, as usual, exclusively on raw materials of the best quality to always be able to guarantee an optimal effect. **Citrus Bergamot by GN Laboratories - because in the end only results count.

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