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Bionic Joints - 400g

Original price €39,90 - Original price €39,90
Original price €39,90
€39,90
€39,90 - €39,90
Current price €39,90
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Joints, tendons and ligaments are all structures that heavily loaded by sports can be. This burden requires that the Joints are always in the best condition, so that all movement sequences performed optimally can be. For this to be the case, it is important to provide the body with everything it needs to maintain the joints, tendons and ligaments. To optimally support this process GN Laboratories Bionic Joints developed. A supplement that numerous effective active ingredients connects with each other to optimally support passive structures of the musculoskeletal system. Bionic Joints from GN Laboratories - because in the end only results count.
  • Comprehensive formula to support joints, ligaments and tendons
  • Scientifically proven ingredients
  • Antioxidant effect
  • Peptan® collagen peptides and OptiMSM®.
  • High dose
  • Easy to dose
  • Proven quality - Made in Germany
Nutritional values and ingredients
Average nutritional valuesper serving 20 gper 100 g% (NRV*)
Vitamins and Minerals:
Calcium (as calcium citrate)200 mg1000 mg25 %
Vitamin C (as L-ascorbic acid)40 mg200 mg50 %
Manganese (as manganese citrate)1 mg5 mg50 %
Boron (as Disodium Tetraborate Decahydrate)1 mg5 mg**
Copper (as copper gluconate)0,5 mg2.5 mg50 %
Selenium (as sodium selenite)27,5 µg137.5 µg50 %
Collagen Matrix:
Peptan® collagen hydrolisate type 1 and type 36000 mg30000 mg**
Peptan® collagen hydrolisate type 21000 mg5000 mg**
Cat's Claw Extract3000 mg15000 mg**
D-Glucosamine HCl1000 mg5000 mg**
Chondroitin sulfate1000 mg5000 mg**
OptiMSM®1000 mg5000 mg**
Hyaluronic acid250 mg1250 mg**
Bromelain250 mg1250 mg**


Ingredients: Collagen hydrolisate type 1 & type 3 (from beef), cat's claw extract, collagen hydrolisate type 2 (from chicken), D-glucosamine hydrochloride, chondroitin sulfate (from beef), methylsulfonylmethane (OptiMSM®), calcium citrate (21% calcium), natural flavor, sodium hyaluronate, maltodextrins, bromelain, acidifier: DL-malic acid, flavor, beet powder (Beta vulgaris), vitamin C (L-ascorbic acid), sweetener: sucralose, sodium borate, sodium selenite, copper gluconate, manganese citrate.

*Percent of the recommended daily intake according to Regulation (EU) No. 1196/2011.

**No nutrient reference values (NRV) available.

Consumption recommendation
Stir 1 scoop (20 g) in at least 400 ml of water and drink this mixture 1x daily. DO NOT EXCEED 2 SCOOPS WITHIN 24 HOURS.
Notes

Food supplements are not intended as a substitute for a balanced and varied diet and healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of small children!

Sources
  1. Wang, H., Chen, W., Li, D., & Yin, Y. (2019). The effects of heavy resistance training on the musculoskeletal system in the elderly. Journal of Orthopaedic Translation, 18, 38-46. doi: 10.1016/j.jot.2018.06.002
  2. Oesser, S., Adam, M., Babel, W., & Seifert, J. (2016). Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Journal of Nutrition, 146(2), 165-173. doi: 10.3945/jn.115.223925
  3. Lippiello, L., Woodward, J., & Karpman, R. (1991). Hydrolyzed collagen for bone and joint disease: An overview. Nutrition and Health, 7(2-3), 69-81.
  4. Moskowitz, R. (2000). Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2), 87-99. doi: 10.1053/sarh.2000.9622
  5. Sahni S, Mangano KM, McLean RR, Hannan MT, Kiel DP. Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Curr Osteoporos Rep. 2015 Oct;13(5):245-55. doi: 10.1007/s11914-015-0282-5. PMID: 26201525.
  6. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999 Apr;69(4):727-36. doi: 10.1093/ajcn/69.4.727. PMID: 10197570.
  7. Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL. Protective effect of total and supplemental vitamin C intake on the risk of hip fracture--a 17-year follow-up from the Framingham Osteoporosis Study. Osteoporos Int. 2009 Nov;20(11):1853-61. doi: 10.1007/s00198-009-0871-6. epub 2009 Feb 19. PMID: 19229531; PMCID: PMC3545813.
  8. Chen JR, Lazarenko OP, Blackburn ML, Ronis MJ, Badger TM. Mitigation of bone loss by fruit and vegetable intake in postmenopausal women. Calcif Tissue Int. 2016 Jun;98(6):597-603. doi: 10.1007/s00223-016-0110-7. epub 2016 Feb 18. PMID: 26892471; PMCID: PMC4876399.
  9. Keen CL, Zidenberg-Cherr S. Manganese toxicity in humans and experimental animals. In: Mertz W, ed. Trace Elements in Human and Animal Nutrition. Vol. 2. 5th ed. New York: Academic Press; 1987:511-527.
  10. Nielsen FH. Boron in human and animal nutrition. Plant Soil. 1997;193(1-2):199-208. doi: 10.1023/A:1004216126069
  11. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1987 Nov;1(5):394-7. doi: 10.1096/fasebj.1.5.3315806. PMID: 3315806.
  12. Kuo SM, Tan CH, Li FY, Lu MC, Cheng FC. Copper-deficiency-induced hypercholesterolemia and atherosclerosis in Japanese quail is not due to changes in plasma angiotensin-converting enzyme activity. J Nutr. 2003 Oct;133(10):3208-12. doi: 10.1093/jn/133.10.3208. PMID: 14519805.
  13. Reginster, J. Y., Deroisy, R., Rovati, L. C., Lee, R. L., Lejeune, E., Bruyere, O., ... & Henrotin, Y. E. (2001). Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. The Lancet, 357(9252), 251-256.
  14. Das, A., & Hammad, T. A. (2017). Efficacy of glucosamine and chondroitin for treatment of osteoarthritis: a literature review. Journal of functional morphology and kinesiology, 2(4), 43.
  15. Houpt, J. B., McMillan, R., Wein, C., Paget-Dellio, S. D., (1999). Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of Rheumatology, 26(11), 2423-2430.
  16. Pavelka, K., Gatterova, J., Olejarova, M., Machacek, S., Giacovelli, G., Rovati, L. C., ... & Glucosamine Sulfate Study Group. (2002). Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine, 162(18), 2113-2123.
  17. Uebelhart, D., Malaise, M., Marcolongo, R., & DeVathaire, F. (1994). Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis and Cartilage, 2(1), 39-48.
  18. Volpi, N. (2009). Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. Journal of Pharmacy and Pharmacology, 61(10), 1271-1280.
  19. Kim, Y. H., Kim, D. H., Lim, H., Baek, D. Y., Shin, H. K., & Kim, J. K. (2009). The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biological and Pharmaceutical Bulletin, 32(4), 651-656.
  20. Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., ... & Elbaz, A. (2011). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC complementary and alternative medicine, 11(1), 50.
  21. osteoarthritis: a systematic review and meta-analysis." Journal of Arthroplasty, 29(10), 2014, pp. 2028-2037. doi: 10.1016/j.arth.2014.04.054.
  22. L. Zdzieblik, S. Oesser, et al. "Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides." Applied Physiology, Nutrition, and Metabolism, 39(4), 2014, pp. 1-8. doi: 10.1139/apnm-2013-0262.
  23. J. Dar, N. Ali, et al. "Efficacy of collagen peptide in joint pain - osteoarthritis and rheumatoid arthritis." Journal of Food Science and Technology, 55(8), 2018, pp. 2791-2797. doi: 10.1007/s13197-018-3263-8
  24. K. Matsukawa, T. Yamasaki, et al. "Inhibitory effects of quercetin on inflammation in the reproductive tracts of female mice." Nutrients, 9(1), 2017, pp. 1-12. doi: 10.3390/nu9010047.
  25. J. Jäger, R. Purpura, et al. "The effects of quercetin supplementation on endurance performance and physical activity in healthy humans." Journal of International Society of Sports Nutrition, 15(11), 2018, pp. 1-14. doi: 10.1186/s12970-018-0216-0.
  26. J. Brien, S. Lemaire, et al. "Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies." Evidence-Based Complementary and Alternative Medicine, 1(3), 2004, pp. 251-257. doi: 10.1093/ecam/neh035.
  27. L. Hale, and M. Chávez. "Bromelain." Journal of the American Association of Nurse Practitioners, 21(5), 2009, pp. 295-300. doi: 10.1111/j.1745-7599.2009.00407.x.
  28. C. Rovetta, and A. Giacovelli. "Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis." Journal of Rheumatology, 26(6), 1999, pp. 1398-1405.
  29. F. Piscoya, J. Rodriquez, et al. "Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis." Inflammation Research, 53(5), 2004, pp. 253-261. doi: 10.1007/s00011-004-1275-7.
  30. A. Allen-Hall, N. Cano, et al. "Effects of herbal components on inflammatory and catabolic gene expression in IL-1β-stimulated human chondrocytes." Journal of Inflammation, 8(1), 2011, pp. 1-11. doi: 10.1186/1476-9255-

Content: 400g Item No.: 6153B

In relation to the musculoskeletal system we often deal with Muscleshow we can best provide them with nutrients, avoid injuries and get the most out of them. However, all these factors are also crucial for the joints. That is why GN Laboratories has developed Bionic Joints developed. Healthy joints, ligaments, tendons and bones are not only for athletes, but for every human being of essential of essential importance. Unfortunately, most people don't realize this until they start experiencing joint problems, pain and limited mobility. Even though sports are actually good for the joints, they can be Competitive sports and strength training with heavy weights can be hard on the joints.. This can sometimes lead to joint wear and painful inflammation of the joints (1). joints (1). Especially for athletes who, on the one hand, put their joints under a lot of strain and, on the other hand, depend on an unrestricted, pain-free function of their joints for their athletic performance and success. unrestricted, pain-free functioning of their joints, optimal optimal joint function is of crucial importance.

Which important aspects does Bionic Joints cover?

The Maintaining and supporting healthy joints encompassed a whole range of different aspects, all of which are equally important. Unlike most other products on the market, which usually focus on only one of these aspects, Bionic Joints covers all of these aspects. Bionic Joints contains a essential building blocks for the development of articular cartilage, including Glucosamine, MSM, Chondroitin and Collagen Hydrolysate.. Unlike painkillers, these ingredients address the root causes of the causes of the problems and do not simply relieve the pain (2). (2). Another aspect that Bionic Joints can affect is the Joint fluid. This serves, among other things, the "lubrication" of the jointsin order to frictionless, painless movements to enable. In addition to this , it helps cushion and compensate for shock loads from jumps and other explosive movements , protecting the articular cartilage from damage. (3). Bionic Joints contains a whole range of ingredientswhich promote optimal production of synovial fluid in the subjects of a study, thuswhich improved the the function of their joints in general (4). (4). In addition to this, it is true that in the case of joint problems it can be quite harmful than to immobilize the affected joints or to move them only in a limited way. Movements without heavy loads contribute significantly to the regeneration of the joints.e contribute. However, such movements are only possible if they can be performed as painlessly as possible - and this is precisely one of the goals of Bionic Joints. This brief summary only scratches the surface of the many effects effects that have been demonstrated for the ingredients of Bionic Joints.. However, it does provide a rough overview of the functions of Bionic Joints.

The ingredients of Bionic Joints

Bionic Joints is composed of a blend of ingredients that scientists say are essential for maintaining healthy, stable bones. necessary for the maintenance of healthy, stable bones, may be of vital importance (5). In addition, it also contains the innovative Bionic Joints Matrixwhich has been designed for the purpose, to provide optimal support for joints, ligaments and tendons.. Already the first mixture lifts Bionic Joints from practically all other joint support products available on the market. These usually do not influence the maintenance and maintenance and promotion of strong and stable bones, but are designed exclusively for joints. In our opinion, this approach is somewhat short-sighted, because what good are healthy joints if the bones where these joints are located are not up to the demands of hard and heavy training sessions?

Calcium is probably the most important mineralwhen it comes to the building and maintaining healthy and stable bones. is at stake. Deficiency of calcium or inadequate absorption of dietary calcium could rapidly lead to bone demineralization and the development of osteoporosis in independent studies (5). A osteoporosis, is characterized by a breakdown of bone substancewhich severely affects the stability of the bones. In addition to insufficient calcium intake, an acidic diet rich in protein and cereal products and poor in fruits and vegetables can also promote calcium deficiency and bone loss (6). Another important ingredient is Vitamin C. While the crucial importance of vitamin D for the stability and health of the bones is well known to manyonly a few know that also vitamin C is also of crucial importance for bone formation. is. In studies, vitamin C inhibited bone resorption in volunteers and was an essential cofactor for collagen and calcitonin synthesis. cofactor for collagen and calcitonin synthesis (7). (7). Calcithonin is critically involved in the body's calcium metabolism and prevents the release of calcium from the bones, thus preventingwhich allows it to counteract demineralization and weakening of the bones in a study (8). (8). Manganese is another active ingredient in Bionic Joints. It is a trace element that is actively involved in cartilage and bone formation (9). (9). Boron is another contained mineral that, according to scientists, has important functions in the body (10). in the body (10). Thus boron prevented the breakdown of vitamin D in the test group of a study and was therefore able to promote promote bone health (11). Copper is a trace element that is a component of the enzyme responsible for the interweaving of the connective tissue proteins collagen and elastin which are responsible for the elasticity and stability of bones, ligaments, tendons and joints.n are necessary (12).

Bionic Joint Matrix

Our revolutionary Bionic Joint Matrix consists of a a multitude of proven ingredientswhich have been scientifically proven to protect joints, ligaments and tendons from overuse and wear and tear. joints and ligaments as well as tendons from overload and wear and tear. could. While other products only contain the "usual suspects" such as. glucosamine, chondroitin and maybe some MSM in their joint support products, GN Laboratories is the only GN Laboratories has gone further and expanded this quite effective basic matrix with a variety of innovative compounds.

Glucosamine is the classic among the joint nutrients. It represents an essential building block of the articular cartilage. Supplementation with this important building block of the joints can ensure, that the raw materials necessary for regeneration and build-up of the articular cartilage are available to the body in sufficient quantities at all times.. Scientific studies come to the conclusion that a glucosamine supplementation for injuries of the articular cartilage bring significant relief for the for the test persons and also significantly improve the mobility of the joints. significantly improve joint mobility (13,14,15). (13,14,15). In addition, glucosamine supplementation glucosamine supplementation stimulated the production of synovial fluid in the subjects, whichwhich "lubricates" the which "lubricates" the joints and makes smooth joint movements possible in the first place (16). (16). Chondroitin sulfate is the second "classic" that is often combined with glucosamine. Also chondroitin is also a component of the articular cartilage representswhich increases the water content of the cartilage tissue erhöht and thereby increase the resistance of the test group of a study to resistance to compression by explosive movements. movements or heavy weights increase could (17). Chondroitin forms a a large part of the mass of articular cartilage and is essential for its structural integrity of the cartilage (18). (18). The third commonly used ingredient is methyl sulfone methane - in short MSM. MSM is a biologically active biologically active form of sulfur, which contains 34% elemental sulfur.. Sulfur is an important component of the collagen contained in articular cartilage and thus MSM provides the body with important building blocks for the construction of articular cartilage (19). In addition, MSM has anti-inflammatory effects (20).

In addition to these three "classics" includes. Bionic Joints also contains Hyaluronic Acid, Collagen, Quercentin, Bromelain and Cat's Claw Extract.. Hyaluronic acid is an important component of articular cartilagewhich in the test group of a study promoted an optimal function of the joint fluid and so helped to cushion impact loads (21). Peptan® brand collagen contains bioactive type 1, IIm and 3 collagen peptides. Peptan® provides bioactive short-chain collagen peptidesn that can be readily absorbed by the body. In subjects of a study, these short-chain collagen peptides stimulated the cartilage cells of the joints to to produce more cartilage tissue, thereby counteracting wear and tear of the articular cartilage and promoting the reconstruction of damaged articular cartilage (22). In one study, supplementation with bioactive collagen peptides was shown to improve joint mobility and cartilage repair in people suffering from joint problems. improved joint mobility and a significant reduction in pain (23). (23). Quercetin is a flavonoidwhich has anti-inflammatory properties anti-inflammatory properties, which in one study in a study to relieve joint pain caused by inflammation (24). (24). As an added bonus, quercetin was shown to be beneficial by a Reduction of post-exercise inflammation and oxidative stress., the and accelerate post-exercise recovery in the test group (25). (25). Bromelain is a proteolytic enzymewhich is also known as pineapple enzyme pineapple enzyme. Bromelain has been shown to reduce inflammation in scientific studies by inhibiting the production of TGF-beta and thereby arthritis symptoms, including swelling, pain, and stiffness of the joints (26, 27). A combination of bromelain with rutoside and trypsin was found by researchers in one study to be as effective as pharmaceuticals in relieving pain. as effective as pharmaceutical analgesics (28). Cat's claw extract is probably one of the most innovative active ingredients in bionic joints and an active ingredient that is often used in connection with joint problems joint problems. In studies, the active ingredient, which is also known as "Uncaria Tomatosa", was shown to have an anti-inflammatory effect anti-inflammatory effect (29). Therefore, it is often used to relieve pain, but it has also beenbut has also been used in the arthritis, rheumatoid arthritis, and osteoarthritis (30). (30).

The The numerous active ingredients we have just discussed have all been the subject of numerous scientific studies.. When we look at the many positive effectsthat have been demonstrated in these studies, it quickly becomes clear, what makes makes Bionic Joints so special. Innovative ingredientswhich in their effect optimally support and improve the common joint supplements. Bionic Joints raises joint support to a new level.lso that nothing stands in the way of optimal performance in the gym. Bionic Joints from GN Laboratories - because in the end only results count.

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