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Berberine - 120 capsules

Original price €24,90 - Original price €24,90
Original price €24,90
€24,90
€24,90 - €24,90
Current price €24,90
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Berberine has the reputation of being able to have numerous positive effects on the body. Many of these effects have been investigated in scientific studies and could be proven in various test groups. These effects range from promoting regeneration and athletic performance, to supporting fat loss and positive effects on blood sugar levels, the cardiovascular system, and health in general. GN Laboratories provides you with Berberine of the highest quality - because in the end, only results matter.

Product Highlights:

  • Numerous effects
  • Scientifically proven
  • High dose
  • 150 mg berberine per capsule
  • Easy to dose capsule form
  • Proven quality - Made in Germany
Nutritional values and ingredients
CompositionPer capsule% (NRV*)
Berberine hydrochloride
150 mg**


Ingredients: Chinese goldenseal extract (95% Berberine HCL), coating agent: hydroxypropylmethylcellulose (vegetable capsule shell), bulking agent: microcrystalline cellulose.

*Percent of the recommended daily intake according to Regulation (EU) No. 1196/2011.

**No nutrient reference values (NRV) available.

Consumption recommendation

Take 1 capsule daily, unchewed, with sufficient water.

Notes

Food supplements are not intended as a substitute for a balanced and varied diet and healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of small children!

Sources
  1. Kulkarni, S. K., & Dhir, A. (2010). Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytotherapy Research, 24(3), 317-324.
  2. Yin, J., Xing, H., Ye, J., & Efficacy, S. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.
  3. Kong, W. J., Wei, J., Abidi, P., Lin, M. H., Inaba, S., Li, C., ... & Li, Y. C. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature medicine, 10(12), 1344-1351.
  4. Zhang, Y., Li, X. J., Yan, F. F., & Sun, H. R. (2010). The effects of berberine on hepatic LDLR mRNA and protein expression in rats with non-alcoholic fatty liver disease. Pharmaceutical biology, 48(3), 315-321.
  5. Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., ... & Ning, G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.
  6. Dong, H., Wang, N., Zhao, L., & Lu, F. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, 2012.
  7. Yin, J., Ye, J., Jia, W., & Efficacy, S. (2008). Effects and mechanisms of berberine in diabetes treatment. Acta Pharmacologica Sinica, 29(10), 1149-1163.
  8. Wang, Y., & Campbell, T. (2017). Berberine enhances insulin receptor signaling and modifies gene expression of glucose metabolism, inflammation, and mitochondrial biogenesis in culturing human skeletal muscle cells. Evidence-Based Complementary and Alternative Medicine, 2017.
  9. Kong WJ, Wei J, Zuo ZY, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10(12):1344-1351. doi:10.1038/nm1135.
  10. Derosa, G., Maffioli, P., & Cicero, A. F. (2015). Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidence to clinical trials. Expert Opinion on Biological Therapy, 15(9), 1297-1306.
  11. Wu, X., Li, Q., Xin, H., Yu, A., Zhong, M., & Guo, X. (2017). Anti-inflammatory and antibacterial activity of berberine in an infected pressure ulcer model. Molecular Medicine Reports, 16(2), 1297-1303.
  12. Sun, X., & Lv, F. (2015). Berberine: pathway validation and drug discovery. Expert Opinion on Drug Discovery, 10(10), 1033-1044.
  13. Dong, H., Wang, N., Zhao, L., Lu, F. E., & Xu, L. J. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-based complementary and alternative medicine, 2012, 591654. https://doi.org/10.1155/2012/591654
  14. Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012). AMP-activated protein kinase: a target for drugs both ancient and modern. Chemistry & biology, 19(10), 1222-1236. https://doi.org/10.1016/j.chembiol.2012.08.019
  15. Wu, L., Xia, M., Duan, Y., Zhang, L., Jiang, H., Hu, X., Yan, H., Zhang, Y., Gu, J., & Xiang, S. (2014). Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Cell death & disease, 5(2), e1306. https://doi.org/10.1038/cddis.2014.274
  16. Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., & Zhang, Y. (2013). Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase. Metabolism, 62(8), 1159-1167. https://doi.org
  17. Yin, J., Xing, H., Ye, J., & Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR, 2019. https://doi.org/10.1002/ptr.6549
  18. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81. https://doi.org/10.1016/j.jep.2014.09.049
  19. Huang, X., Liu, G., Guo, J., Su, Z. (2015). The PI3K/Akt pathway mediates the anti-apoptotic effect of berberine in the rat remnant kidney model. International Journal of Molecular Sciences, 16(2), 3092-3105. doi: 10.3390/ijms16023092
  20. Wang Y, Huang Y, Lam KS. Berberine and its derivatives: a patent review (2009-2012). Expert Opin Ther Pat. 2012;22(8):969-984.
  21. Gerard J, Soriano García J, Romo-Mancillas A, González-Cortazar M, Guzmán-Grenfell AM, Sánchez-Sevilla L. Effect of Berberine on Inflammatory and Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Antioxidants (Basel). 2021;10(2):282. doi: 10.3390/antiox10020282. PMID: 33673056; PMCID: PMC7914246.

Content: 120 capsules Item No.: 6792

What is berberine?

Berberine is an alkaloid that occurs naturally in the roots, bark, leaves and root stem of a number of plants. These plants include barberry, which gave the alkaloid its name. In the field of traditional Chinese medicine and traditional Ayurvedic medicine, berberine has been used for centuries. It is a popular remedy for the treatment of various diseases and ailments. As has now also been demonstrated in numerous studies, berberine possesses a whole range of potentially health-promoting biological effects in the body (1,2,3). Most human studies have examined the effect of berberine on blood sugar control (2), blood lipids (3), and liver function (4). Thus, effects that may not only be beneficial to bodybuilders and other athletes, but may also have a positive impact on health and well-being in general, have been studied.

What are the health benefits of berberine?

Probably the most interesting health benefits of berberine include its effects on the regulation of blood glucose levels. As has been shown in numerous studies, berberine was able to significantly reduce not only the acute blood glucose levels of subjects after a meal, but also HbA1c, which is a marker of the average level of blood glucose over the past few months (5,6). Researchers even concluded in one study that berberine could be as effective as the well-known drug metformin in terms of blood glucose levels (7). According to the researchers, this effect seems to be based on the AMPK activation already described. This activation provides increased transport of glucose into the cells of the body. However, it also includes an acceleration of the repair of the insulin-producing beta cells of the pancreas, as well as an increase in the effect of insulin via an increase in the expression of insulin receptors on the surface of body cells and a slowed breakdown of carbohydrates in the liver (8). In addition to this, judging by various studies, berberine has a number of properties that may support and improve cardiovascular health. These include the ability to lower levels of "bad" LDL cholesterol and blood lipids, and increase levels of "good" HDL cholesterol (9). Other effects that have been shown to have a positive impact on cardiovascular health in subjects include dilatation of coronary arteries and alleviation of cardiac arrhythmias (9,10). Berberine also demonstrated the ability to fight dangerous pathogens such as bacteria, viruses, fungi, and parasites in scientific studies (11). It also exhibited even moderate antibiotic effects, which allowed it to support and improve immune system function in test subjects (11,12). These effects have been known for centuries, and berberine was probably used as an intestinal antiseptic in the ancient Orient because of these properties.

What are the benefits of berberine for athletes and bodybuilders?

Probably one of the most interesting properties of berberine for strength athletes is its ability to activate an enzyme called AMPK in the body. This effect was demonstrated in a study in various test subjects (13). AMPK is also referred to by scientists as the "master switch of metabolism" because of its primary role in regulating metabolism (14). AMPK is an enzyme that is also activated by physical exercise. Among other things, it increases the transport of fatty acids and glucose into muscle cells, where it stimulates the burning of these energy sources (15). At the same time, it actively inhibited the buildup of body fat in test subjects (16), which is also an interesting effect for dieters. For athletes and bodybuilders, the results of the studies result in increased training energy and greater muscle endurance during intense and strenuous training sessions. For figure-conscious individuals who want to lose fat or maintain a low body fat percentage, the stimulation of metabolism and increased fat burning could help them lose weight faster and maintain it more easily (17). The fat loss-promoting effects of berberine have also been demonstrated in practice in a number of clinical studies (2,18,19). Of course, the improved regulation of blood glucose levels by berberine, which we have already discussed, could also potentially further support dieting via prevention of blood glucose fluctuations and cravings. In addition, berberine has pronounced antioxidant properties (20,21) and may thereby protect the body's (muscle) cells and DNA from free radical damage and destruction. Together with the anti-inflammatory properties of berberine that have been found in subjects (2,21), this may promote and accelerate recovery after exercise.

Whether you are an athlete or not, if you look at the various effects that berberine has been able to show in numerous studies, you will quickly realize why it has been used for quite a few years. It has been shown many times in scientific studies, which is why it is an integral part of traditional medicine and is also used to influence various aspects of human health. GN - Laboratories provides berberine of the highest quality class, so that you can benefit from it to the fullest extent. Berberine from GN Laboratories - because in the end only results count.

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